Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity
Hematopoietic stem cell (HSC) transplantation is curative for malignant and genetic blood disorders, but is limited by donor availability and immune-mismatch.Deriving HSCs from patient-matched embryonic/induced-pluripotent stem cells (ESCs/iPSCs) could address these limitations.Prior efforts in murine models exploited ectopic HoxB4 expression Vacuu